Prof. (Dr) Bhudev C. Das

Distinguished Scientist & Chairman & Chair Professor / Dean Faculty of Health & Allied Sciences/ Acting Head AIMT

Amity Institute of Molecular Medicine & Stem Cell Research
 

  • Qualifications

    Graduation : B.Sc.B.Ed(Zoology, Education)-1971,Utkal University

    Post Graduation : M.Sc(Zoology)-1974,Banaras Hindu University

    Doctorate : Ph.D.(Zoology)-1982,Banaras Hindu University

  • Experience

    01 Apr 2014 - Present
    Distinguished Scientist & Chairman & Chair Professor / Dean Faculty of Health & Allied Sciences/ Acting Head AIMT,
    Amity Institute of Molecular Medicine & Stem Cell Research

  • Current Courses Taught

    Anatomy,Physiology and Basic Embryology

    Basic Molecular Biology in Reproduction

    Good Laboratory Practices Ethics and legislation

    Infertility Management and Assisted Reproductive Techniques

    Quality Control, Medico Legal, Regulatory and Ethical Aspects

  • Publications

    Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer ,
    Nature

    Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico & in-vivo insight to vaccine development ,
    Nature

    Curcumin modulates cellular AP-1, NF-KappaB and HPV16 E6 proteins in oral cancer ,
    e-Cancer

    Identification of Human Papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes ,
    Journal of Virological Methods

    Increased Prevalence of Human Papillomavirus Infection in Adolescent Girls Belonging to Different Indian Tribes with varied Socio-Sexual behavior. ,
    Plos One

    Cervical Cancer stem cell selectively overexpress HPV E6 oncoprotein that control stemness and self renewal through upregulation of HES1. ,
    Clinical Cancer Research

    Cervical cancer stem cells manifest radioresistance through upregulation of AP-1 activity ,
    OncoTarget

    Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. ,
    Scientific Reports Nature

    Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico & in-vivo insight to vaccine development. ,
    Scientific Reports Nature

    Functional contribution of microRNAs Let-7a and miR-21 in aberrant STAT3 signaling in cervical cancer. ,
    Molecular Cancer

    Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer. ,
    J Cancer Res Ther

    Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer. ,
    J Cancer Res Ther

    Abrogating hypoxia chemoresistance in glioma cells by a combination of COX-2 inhibitor and Carmustine. ,
    Cancer Letters

    Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. ,
    Molecular Cancer

    Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. ,
    Molecular Cancer

    Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. ,
    Molecular Cancer

    Curcumin modulates cellular AP-1, NF-KappaB and HPV16 E6 proteins in oral cancer. ,
    e-Cancer

    Increased Prevalence of Human Papillomavirus Infection in Adolescent Girls Belonging to Different Indian Tribes with varied Socio-Sexual behavior. ,
    Plos One

    Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein. ,
    BMC Cancer

    What’s New in molecular genetics of cancer. ,
    Cancer News

    Impact of Haplotype TNF-LTA Locus with Susceptibility to Cervical Cancer in Indian Population. ,
    Obstetrics & Gynecology

    Perception of human papillomavirus infection, cervical cancer and HPV vaccination in North Indian population. ,
    Plos One

    Physical state & copy number of high risk human papillomavirus type 16 DNA in progression of cervical cancer. ,
    Indian J Med Res

    Evidence of extrahepatic replication of Hepatitis E virus in human placenta. ,
    Journal of General Virology

    Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study. ,
    Asian Pacific Journal of Cancer

    Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study. ,
    Asian Pacific Journal of Cancer Prevention

    GSTM1 and GSTT1 polymorphism and susceptibility to esophageal cancer in high-and low-risk regions of India. ,
    Tumor Biology

    Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis. ,
    Plos One

    Anticancer Activity of Phyllanthus emblica Linn. (Indian Gooseberry): Inhibition of Transcription Factor AP-1 and HPV Gene Expression in Cervical Cancer Cells. ,
    Nutrition and Cancer

    Downregulation of Tumor Suppressor gene PML in uterine cervical carcinogenesis: Impact of Human papillomavirus infection (HPV). ,
    Gynecol Oncol

    Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India. ,
    Int J Gynaecol Obstet

    Prevalence of human papillomavirus (HPV) among college going girls using self collected urine samples from Tiruchirappalli, Tamilnadu. ,
    Arch Gynecol Obstet

    Modern Approaches to Prevention and Control of Cancer of the Uterine Cervix in Women. ,
    J. Indian Institute of Science

    GSTP1 methylation and polymorphism increase the risk of breast cancer and the effects of diet and lifestyle in breast cancer patients. ,
    Experimental & Therapeutic Medicine

    Viral and bacterial aetiologies of epithelial ovarian cancer. ,
    Eur J Clin Microbiol Infect Dis

    Association analysis of p16 CDKN2A) and RB1 polymorphisms with susceptibility to cervical cancer in Indian population. ,
    Mol Biol Rep

    Anticancer property of Bryophyllum pinnata (Lam.) Oken. leaf on human cervical cancer cells. ,
    BMC Complement Altern Med

    ß-Adrenergic receptor stimulation induces endoplasmic reticulum stress in adult cardiac myocytes: role in apoptosis. ,
    Mol Cell Biochem

    Human papillomavirus infection among young adolescents in India: Impact of vaccination. ,
    J Med Virol

    Prevalence and risk factors of HPV infection among women from various provinces of the world. ,
    Arch GynecolObstet

    High-risk HPV infection among the tribal and non-tribal women of the Andaman and Nicobar Islands, India. ,
    Public Health

    Aberrant promoter methylation and loss of Suppressor of Cytokine Signalling-1 gene expression in the development of uterine cervical carcinogenesis. ,
    cELL oNCOL

    Association of functionally important polymorphism of microsomal epoxide hydrolase gene (EPHX1) with lung cancer susceptibility. ,
    Cancer Invest

    Analysis of carriers of hepatitis B virus from a tertiary referral hospital: Does the viral load change during the natural course of infection? ,
    J Med Virol

    Berberinemodulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. ,
    Mol Cancer

    Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley. ,
    ReceptSignal Transduct

    Evaluation of adefovir& lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. ,
    Indian J Med

    Efficacy of Plasma TGF-ß1 Level in Predicting Therapeutic Efficacy and Prognosis in Patients with Advanced Non-Small Cell Lung Cancer. ,
    Cancer Invest

    Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley-A high risk area. ,
    Mol Carcinog

    Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. ,
    J Gastoenterol Hepatol

    Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women. ,
    BMC Cancer

    High viral load and deregulation of Progesterone receptor signaling pathway: Association with Hepatitis E related poor pregnancy outcome. ,
    J HEPATOL

    Lack of utility of plasma TNF-alpha level in predicting therapeutic efficacy in patients with advanced non-small cell lung cancer. ,
    CYTOKINE

    Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection. ,
    Mol Cancer

    Psychosocial disorders in women undergoing postoperative radiation and chemotherapy for breast cancer in India. ,
    Indian J Cancer

    Application of a Multiplex PCR to cervical cells collected by a paper smear for the simultaneous detection of all mucosal human papillomaviruses and typing of HR HPV types 16 and 18. ,
    J Med Microbiol

    Utility of plasma tumour necrosis factor-alpha and transforming growth factor-beta1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma. ,
    BIOMARKERS

    Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis. ,
    J Recept Signal Transduct Res.

    Plasma DNA level in predicting therapeutic efficacy in advanced non-small cell lung cancer. ,
    Lung Cancer

    Plasma DNA level in predicting therapeutic efficacy in advanced non-small cell lung cancer. ,
    EUR RESPIR J

    Efficacy of circulating plasma DNA as a diagnostic tool for advanced non-small cell lung cancer and its predictive utility for survival and response to chemotherapy. ,
    Lung Cancer

    Plasma nucleosome levels might predict response to therapy in patients with advanced non-small-cell lung cancer. ,
    CLIN LUNG CANCER

    Association of single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer risk in Indian population. ,
    BREAST CANCER RES TREAT.

    Association of TNF-alpha gene promoter polymorphisms with acute viral hepatitis in Indian Population. ,
    DIGESTIVE DISEASES AND SCIENCES

    Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women. ,
    HUMAN IMMUNOLOGY

    Genetic variant of CCND1: Association with HPV-mediated cervical cancer in an Indian population, ,
    BIOMARKERS

    Aberrant Promoter Methylation and Reduced Expression of p16 Gene in Esophageal Squamous Cell Carcinoma from Kashmir Valley: a high-risk area, ,
    Mol. Cell. Biochemistry

    Elimination of High-Risk Human Papillomavirus type HPV16 Infection by ‘Praneem’ Polyherbal Tablet in Women with early Cervical Intraepithelial Lesions, ,
    J CANCER RES. CLIN. ONCOL.

    Mutational spectrum of conserved regions of TP53 and PTEN genes in Kangri cancer (of the skin) in the Kashmiri population, ,
    MUTATION RESEARCH

    An epidemiological study to identify the risk factors with two different types of controls in high-grade cervical lesions including invasive cancer, ,
    EUR CANCER CARE

    Tumour necrosis factor-alpha and soluble Fas ligand as biomakers in non-acetaminophen-induced acute liver failure, ,
    BIOMARKERS

    Trans-activation and expression patterns of Jun and Fos/AP-1 super family proteins in human oral cancer, ,
    INTERNATIONAL JOURNAL OF CANCER

    Transcription factor AP-1 in esophageal squamous cell carcinoma: Alteration in activity and expression during human papillomavirus infection. ,
    BMC Cancer

    Overexpression of STAT3 in HPV-mediated cervical cancer in a North Indian population. ,
    MOL. CELL BIOCHEMISTRY

    Curcumin as an anti-human papillomavirus and anti-cancer compound ,
    Future Science Group

    Higher Prevalence of Human Papillomavirus Infection in Adolescent and Young Adult Girls Belonging to Different Indian Tribes with Varied Socio-Sexual Lifestyle ,
    PLOS

    Cervical Cancer Stem Cells Selectively Overexpress HPV Oncoprotein E6 that Controls Stemness and Self-Renewal through Upregulation of HES1 ,
    American Association for Cancer Research

    Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis ,
    Springer

    Identification of Specific miRNA Signature in Paired Sera and Tissue Samples of Indian Women with Triple Negative Breast Cancer ,
    PLOS

    Knowledge, awareness and attitude on HPV, HPV vaccine and cervical cancer among college students in India ,
    PLOS

    Utility of gene expression signature in treatment decision of breast cancer. ,
    AME Publishing

    Cervical cancer stem cells manifest radio resistance through upregulation of AP-1 activity ,
    Nature

    Clinical utility of RT-PCR in assessing HER 2 gene expression versus traditional IHC and FISH in breast cancer patients ,
    Springer

    Constitutive Activation of NF-?B p50/c-Rel Subunits Contribute in Tumor Aggressiveness and Metastasis during Tongue Carcinogenesis ,
    Impact Journals

    Differential inhibitory effects of curcumin between HPV+ve and HPV-ve oral cancer stem cells ,
    Frontiers

    HPV: Molecular pathways and targets. ,
    Elsevier

  • Projects

    Identification and phenotypic charecterization of Stem ellls in cervical pre-cancer and cancer(DST)
    JC Bose Fellowshipby (DST)

    Development of a novel curcumin folate Drug conjugates for targetted delivery of drug and curcumin (AIB)
    Development of a voel drug conjugateby (ICMR)

  • Affiliations

    AACR Since 01 Jan 2000

 
 
 

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