Faculty Detail

Dr Simran Tandon

Professor

Amity Institute of Molecular Medicine & Stem Cell Research

Qualifications
Graduation : B.Sc(Bio Chemistry)-1989,Punjab University

Post Graduation : M.Sc(Bio Chemistry)-1990,Punjab University

Doctorate : Ph.D.-2000,Postgraduate Institute of Medical Education and Research, Chandigarh

NET : NET ,University Grants Commission
Experience
12 Jan 2015 - Present
Professor,
Amity Institute of Molecular Medicine & Stem Cell Research

01 Jan 2009 - 25 Mar 2013
Asst. Professor,
Jaypee University of Information Technology,
Waknaghat

10 Nov 2000 - 25 Nov 2002
Post-Doc Fellow,
University of Kansas Medical Center,
Kansas, USA

05 Jun 1998 - 30 Oct 1999
Junior Demonstrator,
PGIMER,
Chandigarh

01 Sep 1991 - 30 May 1992
Research Fellow,
University of Roorkee,
Roorkee
Publications
Curr Stem Cell Res Ther ,
Bentham

1. Chemical and physical factors influencing the dynamics of differentiation in embryonic stem cells ,
Bentham

Curr Stem Cell Res Ther ,
Bentham

Urolithiasis

Curr Stem Cell Res Therapy ,
Bentham

J Plant Biochem Biotech ,
Springer

Arch Iran Med

6. Chemical and physical factors influencing the dynamics of differentiation in embryonic stem cells ,
Curr Stem Cell Res Therapy

2. Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells ,
J Plant Biochem Biotech

In vitro inhibition of calcium oxalate crystallization and crystal adherence to renal tubular epithelial cells by Terminalia arjuna ,
Urolithiasis

3. In vitro studies reveal antiurolithic effect of Terminalia arjuna using quantitative morphological information from computerized microscopy ,
Int Braz J Urol

4. Inhibition of Calcium Oxalate Crystallization and Diminution of Oxalate Induced Renal Tubular Epithelial Cell Injury in vitro by Terminalia arjuna. ,
The Journal of Urology supplement

5. In vitro assessment of antilithiatic property of Terminalia arjuna on calcium oxalate crystallization and its cytoprotective role on renal epithelial cells ,
Canadian Urological Association journal supplement

Impact of homeopathic remedies on the expression of lineage differentiation genes: an in vitro approach using embryonic stem cells ,
Homeopathy

8. Mushroom Extracts Induce Human Colon Cancer Cell (COLO-205) Death by Triggering the Mitochondrial Apoptosis Pathway and Go/G1-Phase Cell Cycle Arrest ,
Arch Iran Med

Genetic basis for developmental toxicity due to statin intake using embryonic stem cell differentiation model ,
Hum Exp Toxicol

DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by Ruta graveolens in human colon cancer cells ,
Homeopathy

Evaluation of the Cytotoxic Effects of CAM Therapies: An In Vitro Study in Normal Kidney Cell Line ,
Scientific World Jouranl

Hypocapnia leads to enhanced expression of pluripotency and meso-endodermal differentiation genes in mouse embryonic stem cells. ,
Exp Cell Res

Achyranthes aspera root extracts induce human colon cancer cell (COLO-205) death by triggering the mitochondrial apoptosis pathway and S phase cell cycle arrest. ,
Scientific World Journal

Embryonic Stem Cells: An Alternative Approach to Developmental Toxicity Testing ,
J Pharm Res

Delving into the Antiurolithiatic Potential of Tribulus terrestris Extract Through -In Vivo Efficacy and Preclinical Safety Investigations in Wistar Rats ,
Scientific Reports-Nature Publishing Group

Performance evaluation of isolated electrogenic microalga coupled with graphene oxide for decolorization of textile dye wastewater and subsequent lipid production. ,
Chem. Engg. Journal

Biodecolorization of azo dye Acid Black 24 by Bacillus pseudomycoides: Process optimization using Box Behnken design model and toxicity assessment. ,
Bioresource Technology Report

Disruption of mitochondrial membrane potential coupled with alterations in cardiac biomarker expression as early cardiotoxic signatures in human ES cell-derived cardiac cells. ,
Human & Experimental Toxicology

Role of DHH superfamily proteins in nucleic acids metabolism and stress tolerance in prokaryotes and eukaryotes. ,
International Journal of Biological Macromolecules

Clinical utility of RT-PCR in assessing HER 2 gene expression versus traditional IHC and FISH in breast cancer patients. ,
Breast Cancer

Role of matrix metalloproteinases in degenerative kidney disorders. ,
Current Medical Chem

Human kidney stone matrix: Latent potential to restrain COM induced cytotoxicity and inflammatory response. ,
Chem. Biology Interaction

Response surface methodology based extraction of Tribulus terrestris leads to an upsurge of antilithiatic potential by inhibition of calcium oxalate crystallization processes. ,
PloS one

Cytoprotective and anti-apoptotic role of Terminalia arjuna on oxalate injured renal epithelial cells. ,
Cytotechnology

Mechanistic Insights into the Antilithiatic Proteins from Terminalia arjuna: A Proteomic Approach in Urolithiasis. ,
PloS one

Kidney stone matrix proteins ameliorate calcium oxalate monohydrate induced apoptotic injury to renal epithelial cells. ,
Life Science

Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells. ,
Journal of Plant Biochemistry and Biotechnology

Impact of homeopathic remedies on the expression of lineage differentiation genes: an in vitro approach using embryonic stem cells. ,
Homeopathy

In vitro inhibition of calcium oxalate crystallization and crystal adherence to renal tubular epithelial cells by Terminalia arjuna. ,
Urolithiasis
Projects
Development of herbal product for urolithiasis from Tribulus terrestris(AIB)
Urolithiasis, classified as one of the most painful disorders afflicting mankind since ancient times, affects 2 - 20% population worldwide. One of the important phenomena that characterize urolithiasis is its high recurrence which is ~50% along with the increasing prevalence rate. Calcium containing stones, especially calcium oxalate monohydrate, calcium oxalate dihydrate (weddellite) and calcium phosphate (apatite) are the most commonly occurring ones (75-90%) followed by magnesium ammonium pby (DBT)

Establishment of an assay using human embryonic stem cell derived cardiac precursors from KIND2 cell(AIMMSCR)
Development of a Stem cell based method for screening for cardiotoxicityby (DBT)

Mass spectrometric identification of matrix protein(s) from calcium oxalate stones in nephroli(PGIMER)
Proteomic analysis into antilithiatic proteinsby (ICMR)

In Vitro Approaches to Investigate the Efficacy and Mechanism of Action of Homeopathic Medicines Aga(CCRH)
Screening of homeopathic remedies for their differential anti-cancer activities in various breast and prostate cancer cell lines (which address hormone dependent and independent forms of these cancer) as well as in normal cell lines. by (CCRH)
Activities
Stood 3rd in B.Sc(Hons) Biochemistry in Panjab University,Chandigarh 1988

Cleared JRF-NET UGC_CSIR Exam in 1991

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