Prof. (Dr) Bhudev C. Das

Distinguished Scientist & Chairman & Chair Professor / Dean Faculty of Health & Allied Sciences

Amity Institute of Molecular Medicine & Stem Cell Research
 
  • Qualifications

    Graduation : B.Sc.B.Ed(Zoology, Education)-1971,Utkal University

    Post Graduation : M.Sc(Zoology)-1974,Banaras Hindu University

    Doctorate : Ph.D.(Zoology)-1982,Banaras Hindu University

  • Experience

    01 Apr 2014 - Present
    Distinguished Scientist & Chairman & Chair Professor / Dean Faculty of Health & Allied Sciences,
    Amity Institute of Molecular Medicine & Stem Cell Research

  • Current Courses Taught

    Biomedical Study Design & Clinical Trials

  • Publications

    Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer ,
    Nature

    Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico & in-vivo insight to vaccine development ,
    Nature

    Curcumin modulates cellular AP-1, NF-KappaB and HPV16 E6 proteins in oral cancer ,
    e-Cancer

    Identification of Human Papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes ,
    Journal of Virological Methods

    Increased Prevalence of Human Papillomavirus Infection in Adolescent Girls Belonging to Different Indian Tribes with varied Socio-Sexual behavior. ,
    Plos One

    Cervical Cancer stem cell selectively overexpress HPV E6 oncoprotein that control stemness and self renewal through upregulation of HES1. ,
    Clinical Cancer Research

    Cervical cancer stem cells manifest radioresistance through upregulation of AP-1 activity ,
    OncoTarget

    Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. ,
    Scientific Reports Nature

    Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico & in-vivo insight to vaccine development. ,
    Scientific Reports Nature

    Functional contribution of microRNAs Let-7a and miR-21 in aberrant STAT3 signaling in cervical cancer. ,
    Molecular Cancer

    Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer. ,
    J Cancer Res Ther

    Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer. ,
    J Cancer Res Ther

    Abrogating hypoxia chemoresistance in glioma cells by a combination of COX-2 inhibitor and Carmustine. ,
    Cancer Letters

    Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. ,
    Molecular Cancer

    Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. ,
    Molecular Cancer

    Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. ,
    Molecular Cancer

    Curcumin modulates cellular AP-1, NF-KappaB and HPV16 E6 proteins in oral cancer. ,
    e-Cancer

    Increased Prevalence of Human Papillomavirus Infection in Adolescent Girls Belonging to Different Indian Tribes with varied Socio-Sexual behavior. ,
    Plos One

    Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein. ,
    BMC Cancer

    What’s New in molecular genetics of cancer. ,
    Cancer News

    Impact of Haplotype TNF-LTA Locus with Susceptibility to Cervical Cancer in Indian Population. ,
    Obstetrics & Gynecology

    Perception of human papillomavirus infection, cervical cancer and HPV vaccination in North Indian population. ,
    Plos One

    Physical state & copy number of high risk human papillomavirus type 16 DNA in progression of cervical cancer. ,
    Indian J Med Res

    Evidence of extrahepatic replication of Hepatitis E virus in human placenta. ,
    Journal of General Virology

    Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study. ,
    Asian Pacific Journal of Cancer

    Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study. ,
    Asian Pacific Journal of Cancer Prevention

    GSTM1 and GSTT1 polymorphism and susceptibility to esophageal cancer in high-and low-risk regions of India. ,
    Tumor Biology

    Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis. ,
    Plos One

    Anticancer Activity of Phyllanthus emblica Linn. (Indian Gooseberry): Inhibition of Transcription Factor AP-1 and HPV Gene Expression in Cervical Cancer Cells. ,
    Nutrition and Cancer

    Downregulation of Tumor Suppressor gene PML in uterine cervical carcinogenesis: Impact of Human papillomavirus infection (HPV). ,
    Gynecol Oncol

    Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India. ,
    Int J Gynaecol Obstet

    Prevalence of human papillomavirus (HPV) among college going girls using self collected urine samples from Tiruchirappalli, Tamilnadu. ,
    Arch Gynecol Obstet

    Modern Approaches to Prevention and Control of Cancer of the Uterine Cervix in Women. ,
    J. Indian Institute of Science

    GSTP1 methylation and polymorphism increase the risk of breast cancer and the effects of diet and lifestyle in breast cancer patients. ,
    Experimental & Therapeutic Medicine

    Viral and bacterial aetiologies of epithelial ovarian cancer. ,
    Eur J Clin Microbiol Infect Dis

    Association analysis of p16 CDKN2A) and RB1 polymorphisms with susceptibility to cervical cancer in Indian population. ,
    Mol Biol Rep

    Anticancer property of Bryophyllum pinnata (Lam.) Oken. leaf on human cervical cancer cells. ,
    BMC Complement Altern Med

    ß-Adrenergic receptor stimulation induces endoplasmic reticulum stress in adult cardiac myocytes: role in apoptosis. ,
    Mol Cell Biochem

    Human papillomavirus infection among young adolescents in India: Impact of vaccination. ,
    J Med Virol

    Prevalence and risk factors of HPV infection among women from various provinces of the world. ,
    Arch GynecolObstet

    High-risk HPV infection among the tribal and non-tribal women of the Andaman and Nicobar Islands, India. ,
    Public Health

    Aberrant promoter methylation and loss of Suppressor of Cytokine Signalling-1 gene expression in the development of uterine cervical carcinogenesis. ,
    cELL oNCOL

    Association of functionally important polymorphism of microsomal epoxide hydrolase gene (EPHX1) with lung cancer susceptibility. ,
    Cancer Invest

    Analysis of carriers of hepatitis B virus from a tertiary referral hospital: Does the viral load change during the natural course of infection? ,
    J Med Virol

    Berberinemodulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. ,
    Mol Cancer

    Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley. ,
    ReceptSignal Transduct

    Evaluation of adefovir& lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. ,
    Indian J Med

    Efficacy of Plasma TGF-ß1 Level in Predicting Therapeutic Efficacy and Prognosis in Patients with Advanced Non-Small Cell Lung Cancer. ,
    Cancer Invest

    Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley-A high risk area. ,
    Mol Carcinog

    Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. ,
    J Gastoenterol Hepatol

    Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women. ,
    BMC Cancer

    High viral load and deregulation of Progesterone receptor signaling pathway: Association with Hepatitis E related poor pregnancy outcome. ,
    J HEPATOL

    Lack of utility of plasma TNF-alpha level in predicting therapeutic efficacy in patients with advanced non-small cell lung cancer. ,
    CYTOKINE

    Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection. ,
    Mol Cancer

    Psychosocial disorders in women undergoing postoperative radiation and chemotherapy for breast cancer in India. ,
    Indian J Cancer

    Application of a Multiplex PCR to cervical cells collected by a paper smear for the simultaneous detection of all mucosal human papillomaviruses and typing of HR HPV types 16 and 18. ,
    J Med Microbiol

    Utility of plasma tumour necrosis factor-alpha and transforming growth factor-beta1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma. ,
    BIOMARKERS

    Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis. ,
    J Recept Signal Transduct Res.

    Plasma DNA level in predicting therapeutic efficacy in advanced non-small cell lung cancer. ,
    Lung Cancer

    Plasma DNA level in predicting therapeutic efficacy in advanced non-small cell lung cancer. ,
    EUR RESPIR J

    Efficacy of circulating plasma DNA as a diagnostic tool for advanced non-small cell lung cancer and its predictive utility for survival and response to chemotherapy. ,
    Lung Cancer

    Plasma nucleosome levels might predict response to therapy in patients with advanced non-small-cell lung cancer. ,
    CLIN LUNG CANCER

    Association of single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer risk in Indian population. ,
    BREAST CANCER RES TREAT.

    Association of TNF-alpha gene promoter polymorphisms with acute viral hepatitis in Indian Population. ,
    DIGESTIVE DISEASES AND SCIENCES

    Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women. ,
    HUMAN IMMUNOLOGY

    Genetic variant of CCND1: Association with HPV-mediated cervical cancer in an Indian population, ,
    BIOMARKERS

    Aberrant Promoter Methylation and Reduced Expression of p16 Gene in Esophageal Squamous Cell Carcinoma from Kashmir Valley: a high-risk area, ,
    Mol. Cell. Biochemistry

    Elimination of High-Risk Human Papillomavirus type HPV16 Infection by ‘Praneem’ Polyherbal Tablet in Women with early Cervical Intraepithelial Lesions, ,
    J CANCER RES. CLIN. ONCOL.

    Mutational spectrum of conserved regions of TP53 and PTEN genes in Kangri cancer (of the skin) in the Kashmiri population, ,
    MUTATION RESEARCH

    An epidemiological study to identify the risk factors with two different types of controls in high-grade cervical lesions including invasive cancer, ,
    EUR CANCER CARE

    Tumour necrosis factor-alpha and soluble Fas ligand as biomakers in non-acetaminophen-induced acute liver failure, ,
    BIOMARKERS

    Trans-activation and expression patterns of Jun and Fos/AP-1 super family proteins in human oral cancer, ,
    INTERNATIONAL JOURNAL OF CANCER

    Transcription factor AP-1 in esophageal squamous cell carcinoma: Alteration in activity and expression during human papillomavirus infection. ,
    BMC Cancer

    Overexpression of STAT3 in HPV-mediated cervical cancer in a North Indian population. ,
    MOL. CELL BIOCHEMISTRY

    Curcumin as an anti-human papillomavirus and anti-cancer compound ,
    Future Science Group

    Higher Prevalence of Human Papillomavirus Infection in Adolescent and Young Adult Girls Belonging to Different Indian Tribes with Varied Socio-Sexual Lifestyle ,
    PLOS

    Cervical Cancer Stem Cells Selectively Overexpress HPV Oncoprotein E6 that Controls Stemness and Self-Renewal through Upregulation of HES1 ,
    American Association for Cancer Research

    Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis ,
    Springer

    Identification of Specific miRNA Signature in Paired Sera and Tissue Samples of Indian Women with Triple Negative Breast Cancer ,
    PLOS

    Knowledge, awareness and attitude on HPV, HPV vaccine and cervical cancer among college students in India ,
    PLOS

    Utility of gene expression signature in treatment decision of breast cancer. ,
    AME Publishing

    Cervical cancer stem cells manifest radio resistance through upregulation of AP-1 activity ,
    Nature

    Clinical utility of RT-PCR in assessing HER 2 gene expression versus traditional IHC and FISH in breast cancer patients ,
    Springer

    Constitutive Activation of NF-?B p50/c-Rel Subunits Contribute in Tumor Aggressiveness and Metastasis during Tongue Carcinogenesis ,
    Impact Journals

    Differential inhibitory effects of curcumin between HPV+ve and HPV-ve oral cancer stem cells ,
    Frontiers

    HPV: Molecular pathways and targets. ,
    Elsevier

  • Projects

    Identification and phenotypic charecterization of Stem ellls in cervical pre-cancer and cancer(DST)
    JC Bose Fellowshipby (DST)

    Development of a novel curcumin folate Drug conjugates for targetted delivery of drug and curcumin (AIB)
    Development of a voel drug conjugateby (ICMR)

  • Affiliations

    AACR Since 01 Jan 2000