Faculty Detail

Dr Bhupesh Sharma

Professor

Amity Institute of Pharmacy

Academic Area
Pharmacology
Teaching Interests
Subjects Taught to UGs and PGs - Pharmacology - Pathophysiology - Anatomy and Physiology - Advanced Pharmacology - Pharmacology Lab
Qualifications
Graduation : B.Pharm(Pharmacy)-2003,College of Pharmacy Delhi

Post Graduation : M.Pharm(Pharmacology)-2007,Department of Pharmaceutical Sciences and Drug Research

Doctorate : Ph.D.(Pharmaceutical Sciences (Pharmacology))-2012,Department of Pharmaceutical Sciences and Drug Research
Experience
21 Sep 2015 - Present
Professor,
Amity Institute of Pharmacy

16 Apr 2012 - 19 Sep 2015
Associate Professor and HOD,
School of Pharmacy, BIT, Meerut,
BIT Meerut

06 Jul 2009 - 14 Apr 2012
Senior Lecturer,
Surya School of Pharmacy,
Surya World, Patiala

15 Nov 2006 - 04 Jul 2009
Senior Lecturer,
Innovative COP,
Greater Noida
Research Interests
My research lab is working on pharmacological investigations in the areas of Alzheimer’s disease, vascular dementia, neuropathy, opioid dependence, schizophrenia, psychological stress, Huntington’s disease, endothelial dysfunction, cardio-myopathy, pre- as well as post-conditioning of ischemic heart, arsenic and cadmium neuro as well as cerebrovascular toxicity etc. We have explored various pharmacological targets
Publications
Pharmacological benefits of selective modulation of cannabinoid receptor type 2 (CB2) in experimental Alzheimer's disease ,
Elsevier

Reversal in cognition impairments, cholinergic dysfunction, and cerebral oxidative stress through the modulation of ryanodine receptors (RyRs) and cysteinyl leukotriene-1 (CysLT1) receptors. ,
Bentham Science

Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats. ,
Elsevier

Neuroprotective effect of selective DPP-4 inhibitor in experimental vascular dementia. ,
Elsevier

Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder. ,
Elsevier

Neuroprotective Effects of Agomelatine and Vinpocetine Against Chronic Cerebral Hypoperfusion Induced Vascular Dementia. ,
Bentham Science

Melatonin receptor and KATP channel modulation in experimental vascular dementia. ,
Elsevier

In vivo and in vitro attenuation of naloxone-precipitated experimental opioid withdrawal syndrome by insulin and selective KATP channel modulator. ,
Springer

Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington's disease ,
Elsevier

Protective effects of phosphodiesterase-1 (PDE1) and ATP sensitive potassium (KATP) channel modulators against 3-nitropropionic acid induced behavioral and biochemical toxicities in experimental Hunti ,
Elsevier

Modulation of Transient Receptor Potential Vanilloid Subtype 1 (TRPV1) and Norepinephrine Transporters (NET) Protect Against Oxidative Stress, Cellular Injury, and Vascular Dementia ,
Bentham Science

Pharmacological benefit of I(1)-imidazoline receptors activation and nuclear factor kappa-B (NF-?B) modulation in experimental Huntington's disease ,
Elsevier

Efficacy of bosentan, a dual ETA and ETB endothelin receptor antagonist, in experimental diabetes induced vascular endothelial dysfunction and associated dementia in rats. ,
Elsevier

Pharmacological modulation of I1-imidazoline and a2-adrenoceptors in sub acute brain ischemia induced vascular dementia ,
Bentham Science

Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors. ,
Elsevier

Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascu ,
Elsevier

Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible involvement of PPAR-? agonistic property. ,
SAGE

Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats. ,
Springer

Salutary effect of NF?B inhibitor and folacin in hyperhomocysteinemia-hyperlipidemia induced vascular dementia. ,
Elsevier

Experimental hypertension induced vascular dementia: pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor. ,
Elsevier

Behavioral and biochemical investigations to explore pharmacological potential of PPAR-gamma agonists in vascular dementia of diabetic rats. ,
Elsevier

Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats. ,
Elsevier

Pitavastatin and 4'-hydroxy-3'-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes. ,
Bentham Science

Pharmacological investigations on potential of peroxisome proliferator-activated receptor-gamma agonists in hyperhomocysteinemia-induced vascular dementia in rats. ,
Elsevier

Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats. ,
BioMed Central

Beneficial Effects of Donepezil on L-Methionine Induced Vascular Endothelial Dysfunction and Associated Dementia in Rats ,
JStage

Modulation of celecoxib-and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil ,
SAGE

Exploitation of HIV Protease Inhibitor Indinavir as a Memory Restorative Agent in Experimental Dementia ,
Elsevier
Affiliations
IPS Since 23 Dec 2006

IPGA Since 17 May 2003
Activities
Sharma Bhupesh*. Diabetes in endothelial dysfunction and dementia of vascular origin: Recent pharmacological investigations for its recuperation. PHYTOMEDICINES: An Alternate To Modern Medicine & Their Molecular Expression, GLA University, Mathura, Feb., 2013 (Conference Best Oral Presentation Award).

Sharma Bhupesh and Singh Nirmal. Salubrious Role of Modulator of Nicotinamide Adenine Dinucleotide Phosphate-Oxidase (NADPH-Oxidase) in Experimental Hypertension Induced Vascular Dementia. 44th Indian Pharmacological Society, Manipal, December, 2011 (Oral presentation in Prof. Manjeet Singh Award Session for the Best Paper Presentation in Molecular Pharmacology).

Sharma Bhupesh and Singh Nirmal. Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats. Psychopharmacology 2011; 215 (4): 677-687, DOI: 10.1007/s00213-011-2164-0 (Original Investigation). 44th Indian Pharmacological Society, Manipal, December, 2011 (P. P. Suryakumari Award Session-For research papers published by Indian author/authors, in an Indian or foreign journal on Diabetes mellitus, other endocrinal and metabolic disorders in the last three years).

Sharma Bhupesh and Singh Nirmal. Modulation of Nuclear Factor Kappa-B in Experimental Diabetes Induced Endothelial Dysfunction and Vascular Dementia. 43rd Indian Pharmacological Society, Hyderabad, December, 2010 (Oral presentation in Prof. Manjeet Singh Award Session for the Best Paper Presentation in Molecular Pharmacology).

Pushkar Siddharth and Sharma Bhupesh*. HDAC inhibition in diabetes induced vascular dementia. PHYTOMEDICINES: An Alternate To Modern Medicine & Their Molecular Expression, GLA University, Mathura, Feb., 2013 (Conference Best Poster Presentation Award).
Short Description
Total international impact factor >85 (Cumulative impact of 29 published research papers) Citation index - 460 h-index - 14 i10-index - 16 Abstracts and Presentations - 33 Research Students Supervised Ph. D. Pharmacology Students Guiding- Five (05) M. Pharm. Pharmacology Students Guiding- Eleven (11) M. Pharm. Pharmacology Students Guided- Eighteen (18) B. Pharm. Guided- Seven (7) Researcher in the field of Pharmacology, Main research areas are CNS and CVS. For me "Research is the Best Part of Life". My research lab is working on pharmacological investigations in the areas of Alzheimer’s disease, vascular dementia, neuropathy, opioid dependence, schizophrenia, psychological stress, Huntington’s disease, endothelial dysfunction, cardio-myopathy, pre- as well as post-conditioning of ischemic heart, arsenic and cadmium neuro as well as cerebrovascular toxicity etc. We have explored various pharmacological targets such as histone deacetylase (HDAC), nicotinamide aden

,